ãChirality Control of Screw-Sense in Aib-Polymers: Synthesis and Helicity of Amino Acid Functionalized Polymersã?was published in ACS Macro Letters in 2020. These research results belong to Freudenberg, Jan; Binder, Wolfgang H.. Related Products of 7524-52-9 The article mentions the following:
2-Aminoisobutyric acid (Aib) is an essential amino acid, leading to the formation of peptAibols as microbiol. active peptides and proteins. We here report on the ring-opening polymerization (ROP) of Aib-NCA (N-carboxy-anhydrides), enabling to prepare distinct Aib-polymers up to mol. weights of 1400 g/mol with precise end-group control. ROP of Aib-NCA was accomplished via various amine initiators in frozen and liquid solvent systems, in all cases revealing the desired structures as detected by MALDI-TOF-MS and 1H NMR. We can prove living polymerization behavior until the limit of solubility via inline-IR spectroscopy in both solution and solid state polymerization, characterizing the final polymers via MALDI-TOF-anal. The attachment of chiral (D or L)-amino acids onto the polymer’ headgroup allows to systematically investigate the helical screw-sense of poly(Aib)n, resulting in chiral induction to form either left (M)- or right (P)-handed screw-senses, depending on the chirality of the attached amino acid. The approach is extended toward a switchable, chiral azo-headgroup, able to change chirality of the attached poly(Aib)n via a light-induced trigger, revealing a thermally stable cis-isomer when polymer units are attached. In contrast to many other amino acids easily polymerized into poly(amino-acids) via ring-opening polymerization (ROP) of their resp. N-carboxyanhydrides (NCAs), the ROP of Aib-NCA (N-carboxy-anhydrides) here is novel and opens a general approach toward chiral, end group-modified helixes with a defined screw-sense. In the part of experimental materials, we found many familiar compounds, such as H-Trp-OMe.HCl(cas: 7524-52-9Related Products of 7524-52-9)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Related Products of 7524-52-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics