On June 30, 2020, Yan, Saihong; Liang, Mengmeng; Chen, Rui; Hong, Xiangsheng; Zha, Jinmiao published an article.Synthetic Route of 6197-30-4 The title of the article was Reproductive toxicity and estrogen activity in Japanese medaka (Oryzias latipes) exposed to environmentally relevant concentrations of octocrylene. And the article contained the following:
The growing use of octocrylene in sunscreens has posed a great threat to aquatic organisms. In the present study, to assess its reproductive toxicity and mechanism, paired Japanese medaka (Oryzias latipes) (F0) were exposed to OC at nominal concentrations of 5, 50, and 500μg/L for 28 d. Significant increases were observed in the gonadosomatic index and hepatosomatic index of F0 medaka at 500μg/L OC (p < 0.05) without significant differences in fecundity. Significant increases in the percent of mature oocytes were observed at 5 and 500μg/L OC, in which contrary to the percent of spermatozoa (p < 0.05). The plasma sex hormones and vitellogenin levels significantly increased in males at all treatments and in females at 50 and 500μg/L OC (p < 0.05). In addition, the levels of fshβ and lhβ in the brains and the levels of fshr, lhr and cyp17α in the gonads were significantly upregulated in males at all treatments (p < 0.05), in line with those of ar, erα, erβ and cyp19β in the brains of male and female. The upregulation of vtg in male and female livers was observed only at 500μg/L OC and upregulation of star and hsd3β was observed in testis at all treatments (p < 0.05). Continued exposure to OC significantly induced increases in the time to hatching, morphol. abnormality rates, and cumulative death rates of F1 embryos, inconsistent with body length of F1 larvae (p < 0.05). The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Synthetic Route of 6197-30-4
The Article related to oryzias reproductive toxicity estrogen octocrylene, embryonic development, endocrine disrupting, histopathology, japanese medaka (oryzias latipes), octocrylene, Toxicology: Other and other aspects.Synthetic Route of 6197-30-4
Referemce:
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