Thota, V. Narasimharao; Ferguson, Michael J.; Sweeney, Ryan P.; Lowary, Todd L. published an article in 2018, the title of the article was Synthesis of the Campylobacter jejuni 81-176 Strain Capsular Polysaccharide Repeating Unit Reveals the Absolute Configuration of its O-Methyl Phosphoramidate Motif.COA of Formula: C10H14O3 And the article contains the following content:
The O-Me phosphoramidate (MeOPN) motif is a non-stoichiometric modification of capsular polysaccharides (CPS) in â?0 % of all Campylobacter jejuni strains. Infections by C. jejuni lead to food-borne illnesses and the CPS they produce are key virulence factors. The MeOPN phosphorus atom in these CPS is stereogenic and is found as a single stereoisomer. However, to date, the absolute stereochem. at this atom has been undefined. We report the synthesis of the three repeating units found in C. jejuni 81-176 CPS; one of these possesses a MeOPN group. In the course of these studies we established that the stereochem. of the phosphorus atom in this MeOPN group is R. These studies represent the first unequivocal proof of stereochem. of this group in any C. jejuni CPS. The compounds produced are anticipated to be useful tools in investigations targeting the function and biosynthesis of this structurally-interesting modification, which so far has only been identified in campylobacter. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).COA of Formula: C10H14O3
The Article related to amino trisaccharide synthon capsular polysaccharide campylobacter jejuni, 6-deoxyheptose, nmr spectroscopy, capsular polysaccharide, glycosylation, phosphoramidate, Carbohydrates: Amines and other aspects.COA of Formula: C10H14O3
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