In an article, author is Nikiforova, E. A., once mentioned the application of 619-45-4, Name: Methyl 4-aminobenzoate, Name is Methyl 4-aminobenzoate, molecular formula is C8H9NO2, molecular weight is 151.16, MDL number is MFCD00007891, category is esters-buliding-blocks. Now introduce a scientific discovery about this category.
Reformatsky Reaction of 1-Aryl-3-(2-hydroxyphenyl)prop-2-en-1-ones with Methyl 1-Bromocyclohexanecarboxylate
1-Aryl-3-(2-hydroxy-5-R-phenyl)prop-2-en-1-ones reacted with the Reformatsky reagent derived from methyl 1-bromocyclohexanecarboxylate to give 4-(2-aryl-2-oxoethyl)-6-R-2H,4H-spiro[[1]benzopyran-3,1 ‘-cyclohexan]-2-ones. The products are formed as a result of intramolecular cyclization of the adduct of the organozinc reagent and substituted chalcone via nucleophilic attack of the phenoxide oxygen atom on the ester carbonyl carbon atom. No cyclization products resulting from attack of the enolate oxygen atom on the ester carbonyl carbon atom were detected.
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