On May 18, 2020, Roy, Arpita; Samanta, Subhendu; Singha, Koushik; Maity, Pritiprasanna; Kumari, Nimmy; Ghosh, Animesh; Dhara, Santanu; Pal, Sagar published an article.Formula: C12H18O5 The title of the article was Development of a Thermoresponsive Polymeric Composite Film Using Cross-Linked β-Cyclodextrin Embedded with Carbon Quantum Dots as a Transdermal Drug Carrier. And the article contained the following:
Polymeric nanocomposite films are used as promising transdermal drug carriers because of the improved patient compliance, easy application on skin, and noninvasiveness. A thermoresponsive polymeric composite film has been developed here through the deposition of carbon quantum dots (CQDs) on functionalized β-cyclodextrin (β-CD). The composite has been developed by grafting of poly(N-vinyl caprolactam) on β-CD, followed by crosslinking of diethylene glycol dimethacrylate and subsequent deposition of CQDs. CQDs have been prepared from waste pomegranate peels via a hydrothermal method. To enlighten the thermoresponsive nature of the composite film, lower critical solution temperature, as well as temperature-dependent swelling behavior, has been studied. The composite demonstrates excellent rheol. features. The developed polymeric composite film is nontoxic toward NIH 3T3 fibroblast cell lines. On the deposition of CQDs on the copolymer, the penetration power and fluorescent property have been improved, which help to track the cells in vitro. This film is worthy to be applied to the skin. It can efficiently load lidocaine hydrochloride monohydrate (LHM). In vitro and ex vivo skin permeation profiles reveal the sustained release behavior of loaded LHM at average skin temperature and pH. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Formula: C12H18O5
The Article related to field carbon quantum dot transdermal drug carrier polymer cyclodextrin, biocompatible, carbon quantum dots, composite film, cyclodextrin, drug delivery, hydrogel, Pharmaceuticals: Pharmaceutics and other aspects.Formula: C12H18O5
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