On February 21, 2020, Geng, Xueyun; Wang, Guirong; Guo, Zhongwu; Gu, Guofeng published an article.Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) glutarate The title of the article was Synthesis of the Oligosaccharides of Burkholderia pseudomallei and B. mallei Capsular Polysaccharide and Preliminary Immunological Studies of Their Protein Conjugates. And the article contained the following:
Efficient strategies were developed for the synthesis of 6-deoxy-D-manno-heptopyranose and its β-(1 â?3)-linked oligomers as fragments of the common and major capsular polysaccharide, type I O-PS, of Burkholderia pseudomallei and Burkholderia mallei. The unusual heptose was synthesized from mannose, highlighted by the facile Wittig reaction and anti-Markovnikov hydroboration of the resultant olefin. The difficult β-mannosidic linkage in the oligosaccharides was achieved in high stereoselectivity by H-bond-mediated aglycon delivery. All of the oligosaccharides were conjugated with the carrier protein CRM197. Preliminary immunol. evaluations of the resultant glycoconjugates in mice verified their efficacy to elicit high titers of IgG antibodies and robust T-cell-dependent immune responses. It was also found that the trisaccharide conjugates provoked the strongest immune responses, worthy of further in-depth study for vaccine development. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) glutarate
The Article related to igg igm antibody oligosaccharide preparation vaccine glycosylation immunol protein, Carbohydrates: Oligosaccharides and other aspects.Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) glutarate
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