On January 27, 2017, Frings, Marcus; Bolm, Carsten; Blum, Andreas; Gnamm, Christian published an article.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was Sulfoximines from a Medicinal Chemist’s Perspective: Physicochemical and in vitro Parameters Relevant for Drug Discovery. And the article contained the following:
Sulfoximines, sulfondiimides and sulfonimidamides are fascinating but not yet fully explored variants of the common sulfone or sulfonamide motif. In this study, we report the physicochem. and in vitro properties of sulfoximines and compare them with related analogs and isosteres. Furthermore, we present a matched mol. pair anal. of compounds from drug discovery projects within Boehringer Ingelheim. We demonstrate that the sulfoximine moiety is a chem. stable, comparatively polar and weakly basic functional group, often leading to favorable aqueous solubility, permeability and metabolic stability. Moreover, their addnl. vectors at nitrogen enable simple chem. modifications and thus facilitate exploration and fine-tuning of the mol. properties. We conclude that sulfoximines and their congeners do not exhibit any intrinsic flaw but significantly enrich the toolbox of medicinal chemists. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
The Article related to sulfoximine preparation physicochem property drug discovery, metabolic stability, permeability, solubility, sulfondiimides, sulfonimidamides, sulfoximines, synthesis, Pharmacology: Structure-Activity and other aspects.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
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