On October 15, 2019, Zeng, Xiaoming; Luo, Meiming; Zhang, Xue; Ling, Liang published a patent.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Method for synthesizing cis-trifluoromethyl cyclohexane derivative and heterocyclic compound by hydrogenation. And the patent contained the following:
The title method comprises adding trifluoromethyl arene or trifluoromethyl heterocyclic compound, cyclic (alkyl) (amino) carbene ruthenium complex catalyst and 4Å mol. sieve in organic solvent (n-hexane or 1,2-dichloroethane), introducing hydrogen gas, reacting under stirring at 40-60°C for 24 h, filtering, washing with dichloromethane, purifying by silica gel column chromatog. to obtain cis-trifluoromethyl cyclohexane derivative or cis-trifluoromethyl heterocyclic compound The invention has simple process, easily available raw material, mild reaction condition, wild application range and high selectivity. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
The Article related to trifluoromethyl cis cycloalkane saturated heterocycle diastereoselective preparation, heteroarene arene cycloalkyl amino carbene rhodium catalyst dearomative reduction, Alicyclic Compounds: Cyclohexanes and other aspects.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
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