On September 30, 2022, Liao, Jun; Pan, Bo; Zhuo, Xiaobin; Liao, Guochao; Gao, Yun; Yao, Zhenzhen; Wang, Lianghua; Wu, Qiuye; Pan, Weihua; Jiao, Binghua; Zhao, Qingjie published an article.Computed Properties of 79642-50-5 The title of the article was β-1,2-Mannan-based glycoconjugates as potential antifungal vaccines. And the article contained the following:
Phosphorylated di-, tri- and tetra-saccharides of β-1,2-mannan antigen derived from Candida albicans (C. albicans) cell wall were synthesized and covalently conjugated with keyhole limpet hemocyanin (KLH) and human serum albumin (HSA) via a bifunctional linker under mild conditions. The semi-synthetic β-1,2-mannoside-KLH conjugates were evaluated for the immunization of BALB/c mice. The ELISA results revealed that all three conjugates could elicit high levels of specific IgG antibodies and the acquired antisera could effectively identify the β-1,2-mannan epitope. Furthermore, the immunofluorescence and flow cytometry assays also uncovered that the induced antibodies, especially that obtained from immunization with β-1,2-mannotriose-KLH conjugate (1b), could bind well to fungi cell. Eventually, the structure-immunogenicity relationship anal. of β-mannan showed that the length of oligo-β-mannoses had a big impact on their immunogenicity and β-1,2-mannotriose showed the strongest immunogenicity. The results suggested the great potential of β-1,2-mannotriose-KLH conjugate as an antifungal vaccine candidate. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Computed Properties of 79642-50-5
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