Lopez Rivas, Paula; Muller, Christoph; Breunig, Christian; Hechler, Torsten; Pahl, Andreas; Arosio, Daniela; Belvisi, Laura; Pignataro, Luca; Dal Corso, Alberto; Gennari, Cesare published an article in 2019, the title of the article was β-Glucuronidase triggers extracellular MMAE release from an integrin-targeted conjugate.Name: Bis(2,5-dioxopyrrolidin-1-yl) glutarate And the article contains the following content:
A non-internalizing αvβ3 integrin ligand was conjugated to the anticancer drug MMAE through a β-glucuronidase-responsive linker. In the presence of β-glucuronidase, only the conjugate bearing a PEG4 spacer inhibited the proliferation of integrin-expressing cancer cells at low nanomolar concentrations, indicating important structural requirements for the efficacy of these therapeutics. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Name: Bis(2,5-dioxopyrrolidin-1-yl) glutarate
The Article related to glucuronidase extracellular mmae release integrin targeted conjugate, Pharmaceuticals: Formulation and Compounding and other aspects.Name: Bis(2,5-dioxopyrrolidin-1-yl) glutarate
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics