On December 31, 2014, Osawa, Tsutomu; Kizawa, Tomoko; Ikeda, Shinji; Kitamura, Takayuki; Inoue, Yoshihisa; Borovkov, Victor published an article.SDS of cas: 3976-69-0 The title of the article was Enhanced enantioselectivity in the heterogeneous catalytic hydrogenation of acetoacetate esters into the corresponding 3-hydroxybutyrates using commercial nickel powder. And the article contained the following:
Heterogeneous catalytic hydrogenation of acetoacetic acid esters over tartaric acid/NaBr-modified Ni powder is a critical function of the steric bulk of the ester moiety to afford quant. 3-hydroxybutyrate in 94% enantiomeric excess when Et and i-Bu esters were used, providing a facile route to optically active 3-hydroxybutyrates. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).SDS of cas: 3976-69-0
The Article related to acetoacetate ester catalytic hydrogenation hydroxybutyrate enantioselectivity nickel catalyst, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 3976-69-0
Referemce:
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