Elsaidi, Hassan R. H.; Lowary, Todd L. published an article in 2014, the title of the article was Inhibition of Cytokine Release by Mycobacterium tuberculosis Phenolic Glycolipid Analogues.Recommanded Product: 707-07-3 And the article contains the following content:
Infection by Mycobacterium tuberculosis causes tuberculosis, a disease characterized by alteration of host innate and adaptive immunity. These processes are mediated by a series of bacterial biomols., among which phenolic glycolipids (PGLs) and the related p-hydroxybenzoic acid derivatives have been suggested to play important roles. To probe the importance of structural features of these glycans on cytokine modulation, we synthesized three M. tuberculosis PGL analogs (1-3), which differ from the native glycoconjugates by possessing a simplified lipid aglycon. The ability of 1-3 to modulate the release of proinflammatory cytokines (TNF-α, IL-1β, IL-6, MCP-1) and nitric oxide (NO) was evaluated. None of the compounds stimulated the secretion of these signalling mols. However, all showed a Toll-like Receptor 2-mediated, concentration-dependent inhibition profile that was related to the methylation pattern on the glycan. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Recommanded Product: 707-07-3
The Article related to mycobacterium phenolic glycolipid cytokine, toll-like receptors, cytokines, glycolipids, immunomodulators, mycobacteria, tuberculosis, Immunochemistry: Interferons and Lymphokines and other aspects.Recommanded Product: 707-07-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics