121-98-2, Name is Methyl 4-methoxybenzoate, molecular formula is C9H10O3, HPLC of Formula: C9H10O3, belongs to esters-buliding-blocks compound, is a common compound. In a patnet, author is Pham, Quyen T., once mentioned the new application about 121-98-2.
Iodine-mediated formal [3+2] annulation for synthesis of furocoumarin from oxime esters
A novel synthesis of furocoumarins was developed by a reaction between oxime esters and 4-hydroxycoumarins. The reaction was proposed to undergo radical mechanism mediated by iodine, a cheap and common laboratory reagent. Mechanistic studies showed the key for the successful transformation was the presence of alpha-iodoimine intermediate which facilitated the ring-closing step. The developed conditions produced good functional group tolerance with a wide range of high-profile furocoumarin product. The potential for this strategy to be applied in other syntheses of heterocyclic compounds is highly achievable.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 121-98-2 help many people in the next few years. HPLC of Formula: C9H10O3.