Fan, Zhiping; Zhang, Yemin; Ji, Jinkai; Li, Xinsong published an article in 2015, the title of the article was Hybrid polypeptide hydrogels produced via native chemical ligation.Synthetic Route of 6038-19-3 And the article contains the following content:
Biocompatible crosslinking is a key approach for developing biomedical hydrogels and scaffolds. In this report, native chem. ligation (NCL) was utilized to prepare biocompatible and biodegradable hydrogel using naturally derived poly(γ-glutamic acid) and ε-poly-lysine as the backbone without any additive and byproduct. First, thiolactone grafted poly(γ-glutamic acid) (PGA-HC) and cysteine grafted ε-poly-lysine (EPL-C) precursors were synthesized. Their structure was confirmed by NMR (NMR). After that, NCL crosslinking of PGA-HC and EPL-C precursors was triggered by simply blending their buffer solutions without any additive at room temperature, resulting in a hybrid polypeptide hydrogel. The crosslinking approach was verified by Fourier transform IR spectroscopy (FTIR) anal. The equilibrium water content, morphol., degradation rate and mech. properties of the hybrid hydrogels were characterized in detail. The results revealed the NCL hybrid hydrogels had tunable gelation time, water content and mech. properties by adjusting precursor composition Furthermore, the biocompatibility of hybrid hydrogels was confirmed by MTT assay. These characteristics provide a potential opportunity for the NCL hybrid polypeptide hydrogels as wound dressings, skin fillings, drug delivery vehicles and tissue regeneration matrixes. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Synthetic Route of 6038-19-3
The Article related to hybrid polypeptide hydrogel native chem ligation, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Synthetic Route of 6038-19-3
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