On October 16, 2015, Young, Ian S.; Haley, Matthew W.; Tam, Annie; Tymonko, Steven A.; Xu, Zhongmin; Hanson, Ronald L.; Goswami, Animesh published an article.Application of 3976-69-0 The title of the article was A Scalable Synthesis of (R,R)-2,6-Dimethyldihydro-2H-pyran-4(3H)-one. And the article contained the following:
A scalable synthesis of (R,R)-2,6-dimethyldihydro-2H-pyran-4(3H)-one is reported. Key to this strategy is the Ti(OiPr)4-catalyzed Kulinkovich cyclopropanation of silyl protected (R)-Et 3-hydroxybutanoate, and subsequent oxidative fragmentation of the cyclopropanol. The resulting vinyl ketone intermediate was then subjected to oxidative Heck cyclization to form the enone substrate required for conjugate addition A diastereoselective copper-catalyzed Grignard addition procedure was implemented to install the requisite Me group, with the inclusion of 1,3-bis(diphenylphosphino)propane and trimethylsilyl chloride greatly increasing the robustness of this process. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Application of 3976-69-0
The Article related to pyranonr dimethyldihydro preparation kulinkovich cyclopropanation oxidative fragmentation cyclization, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.Application of 3976-69-0
Referemce:
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