On February 5, 2021, Kieslich, David; Christoffers, Jens published an article.Category: esters-buliding-blocks The title of the article was Formation of δ-Lactones by Cyanide Catalyzed Rearrangement of α-Hydroxy-β-oxoesters. And the article contained the following:
δ-Valerolactone derivatives such as I are formed by cyanide-catalyzed ring-transformation of cyclic α-hydroxy-β-oxoesters such as II (R = HO). This unprecedented reaction defines a new synthetic methodol., and the products are obtained in up to quant. yields. Several alkyl substitutions as well as different ester residues are tolerated. Furthermore, benzo- and heteroarene-annulated starting materials such as II (R = HO) are converted without difficulty. As an addnl. benefit, the starting materials are straightforwardly accessed by cerium-catalyzed aerobic α-hydroxylation of readily available β-oxoesters such as II (R = H). The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Category: esters-buliding-blocks
The Article related to valerolactone preparation, cyclic hydroxyoxoester preparation ring transformation cyanide catalyst, oxoester aerobic hydroxylation cerium catalyst, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics