On October 17, 1974, Wuensch, Erich; Wendlberger, Gerhard; Jaeger, Ernst; Scharf, Regine; Deimer, Karl H.; Stocker, Hans published a patent.Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Norleucine-13-motiline. And the patent contained the following:
Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Glu-Arg-Nle-Glu-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln (I) was prepared by successive coupling and deblocking of Arg(HBr)-Asn-Lys(CO2CMe3)-Gly-Gln-OCMe3.HBr, PhCH2O2C-Glu(OCMe3)-Glu(OCMe3)-Lys-(CO2CMe3)-Glu(OCMe3)-OH, PhCH2O2C-Arg[δ,ω – (CO2CH2Ph)2]Nle-OH, PhCH2O2C-Glu(OCMe3)-Leu-Gln-OH, Thr(CMe3)-Tyr(CMe3)-Gly-OH, and Me3CO2C-Phe-Val-Pro-Ile-Phe-OH, which were prepared by standard coupling methods. I, after purification on ion exchange resin, had 90% of the activity of naturally occurring motilin. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
The Article related to motilin norleucine analog, stomach motilin norleucine analog, Synthesis of Amino Acids, Peptides, and Proteins: Peptides and other aspects.Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
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