On December 14, 2006, Degrado, William F.; Bennett, Joel S.; Snyder, Seth Elliot; Choi, Sungwook published a patent.Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Preparation of prolyl dipeptides as inhibitors of the α2β1/gpIa-IIa integrin. And the patent contained the following:
The invention discloses novel compounds I [X is alkylidene; R1 is aralkylamino, aryl- or alkylsulfonylamino, carbalkoxymethyl, aralkoxycarbonylamino, NHSO2R2, where R2 is aryl, alkyl, aralkyl, aralkoxy, aralkylamino, arylamino, or alkylamino; R3 is halo, nitro, aryl, amino, alkyl, alkoxy, alkylsulfonyl, etc.; R4 is amino, hydroxy, aralkoxy, arylamino, aroylamino; R5 is H or alkyl; R6 is H or :O; A is SO2, PO2, CO2, CO; D is optional and may be one or more CH2 groups; E is aryl or heteroaryl; n, q are 0-2; m is 0 or 1; one of the three dashed-line portions may represent a double bond] or a stereoisomer, prodrug, pharmaceutically-acceptable salt, or N-oxide, which inhibit the integrin α2β1/GPIa-IIa receptor and are useful for the treatment of α2β1-affected disease states. Thus, prolyl peptide II was prepared and showed IC50 = 15 nM for inhibition of platelet adhesion to type I collagen. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
The Article related to prolyl peptide preparation inhibitor integrin, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
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