In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37746-78-4, name is (E)-Ethyl 4-bromobut-2-enoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 37746-78-4
The compound of formula 7-4 (3.0 g, 8.7 mmol, 1 eq) was dissolved in acetonitrile,Ethyl bromocrotonate (1.86 g, 9.6 mmol, 1.1 eq) and potassium carbonate (2.42 g, 17.5 mmol, 2 eq) were added. After the addition, the temperature was raised to 85 C. and the reaction was continued overnight.After the completion of the reaction by thin layer chromatography, the mixture was filtered and spin-dried. Ethyl acetate and water were dissolved and diluted. The layers were separated, and the aqueous phase was extracted with ethyl acetate. The organic phase was combined.After washing with saturated saline, it was dried over anhydrous sodium sulfate, filtered, and spin-dried to obtain 3.94 g of a brown oil (compound of formula 7-5) in 98% yield.
The synthetic route of 37746-78-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Yangfan Pharmaceutical Technology Co., Ltd.; Chen Youxi; Gao Fei; He Lidong; (80 pag.)CN104109143; (2018); B;,
Ester – Wikipedia,
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