Hu, Huayou; Liu, Yong; Xu, Juan; Kan, Yuhe; Wang, Chao; Ji, Min published an article in 2014, the title of the article was Palladium catalyzed oxidative Suzuki coupling reaction of indolizine at the 3-position using oxygen gas as the only oxidant.Formula: C11H11NO2 And the article contains the following content:
A Pd(OAc)2/O2 catalytic system with or without ligands was developed for an oxidative Suzuki coupling reaction of indolizines at the 3-position through C-H activation. The unwanted dimerization of 2,3-unsubstituted indolizines was inhibited by the addition of picolinic acid as a ligand. 1,2-Disubstituted indolizines that do not easily dimerize were reacted smoothly with arylboronic acids under ligand-free conditions. Furthermore, broad group tolerance was observed for both indolizines and arylboronic acids. Mild conditions, a broad array of starting materials and the use of a green oxidant are the advantages of this method. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Formula: C11H11NO2
The Article related to boronic acid aryl regioselective oxidative suzuki coupling indolizine, indolizine aryl preparation green chem, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C11H11NO2
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