On September 7, 2021, Huang, Huidan; Zhu, Li; Zhang, Chao; Liu, Xiaoping published a patent.COA of Formula: C17H26O7S The title of the patent was Preparation of hydroxypyranone based compound for targeting ubiquitination and degradation of tyrosinase. And the patent contained the following:
The present invention relates to the preparation of hydroxypyranone based compound for targeting ubiquitination and degradation of tyrosinase. In particular the hydroxypyranone based compound I and II (wherein, the linking chain I = triazole derivative or acetamide derivative, the linking chain II = triazole derivative) was prepared According to the inventive method, a Tyr inhibitor, kojic acid, is covalently bound to Pomalidomide or a VHL enzyme targeting ligand via a connecting chain to obtain a compound targeting a Ubiquitinated degradation tyrosinase with a specific structure; the inventive method has simple operation and mild conditions; the inventive product can significantly inhibit the activity of a vegetable, inhibit the production of melanin, have a significant anti-melanoma effect, can significantly prolong the insurance period of a tyrosinase and fruit and have broad application prospects in medicine, food and cosmetics. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).COA of Formula: C17H26O7S
The Article related to hydroxypyranone derivative preparation tyrosinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.COA of Formula: C17H26O7S
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