On September 30, 2021, Choi, Si Woo; Ryu, Soo Hee; Ryu, Ji Hoon; Son, San Ha; Lee, Hwa Jin; Kim, Seong Hoon; Nam, Boas; Min, Im Suk; Ryu, Hye Guk; Kang, Keum Young published a patent.Reference of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate The title of the patent was Preparation of pyrimidodiazepine derivatives as PLK1 selective degradation inducers for the treatment and prevention of PLK1-related diseases. And the patent contained the following:
The invention relates to preparation of pyrimidodiazepines that induce selective polo-like kinase 1 (PLK1) degradation Specifically, the invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chem. linker. The example compound I was prepared via 6-steps synthesis using 4-bromobutanoic acid as starting material (procedure given). The compounds of the invention may be effectively utilized in prevention and treatment of PLK1-related diseases. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Reference of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate
The Article related to pyrimidodiazepine preparation plk1 degradation inducer disease treatment prophylaxis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Reference of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate
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