On March 29, 2007, Abbott, Philip; Bonnert, Roger Victor; Brough, Stephen; Chohan, Kamaldeep; McInally, Thomas; Thom, Stephen; Isobe, Yoshiaki; Nakamura, Kei; Tojo, Shingo published a patent.Electric Literature of 142327-44-4 The title of the patent was Purine derivatives for the treatment of viral or allergic diseases and cancers. And the patent contained the following:
Purine derivatives, such as I [R = N-bound nitrogen containing heterocycle, such as 3-pyrrolidinyl, 3-azetidinyl or 1-methyl-4-piperidinyl; R3 = CH2CO2Me, R4 = H, or R3 = H, R4 = CH2CO2Me; X = alkylene linking group, such as (CH)n, n = 3, 4], were prepared for use in immunomodulating pharmaceutical compositions which are useful in the treatment of diseases or conditions in which modulation of TLR7 activity is beneficial. These diseases or conditions may include allergic or viral diseases, cancers, asthma, COPD, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, cancer, hepatitis B, hepatitis C, HIV, HPV, bacterial infections and dermatosis. Thus, purine derivative I [R = 4-piperidinyl, R3 = CH2CO2Me, R4 = H; X = (CH2)3] was prepared in 8 steps starting from 2,6-dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine, BuONa, Br(CH2)3NHCO2CMe3, 4-oxo-1-piperidinecarboxylic acid tert-Bu ester, and OHC-3-C6H4CH2CO2Me. The prepared purine derivatives were tested for interferon inducing activity in rat spleen cells and for activation of recombinant human TLR7. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Electric Literature of 142327-44-4
The Article related to purine derivative preparation immunomodulator toll like receptor activity, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Electric Literature of 142327-44-4
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