On September 17, 2003, Hama, Takuo; Liu, Xiaoxiang; Culkin, Darcy A.; Hartwig, John F. published an article.Formula: C12H15NO4 The title of the article was Palladium-Catalyzed α-Arylation of Esters and Amides under More Neutral Conditions. And the article contained the following:
Two procedures for the α-arylation of carbonyl compounds, under more neutral conditions than those for reactions of aryl halides with alkali metal enolates, are reported. The first procedure rests upon the development of catalysts bearing the hindered pentaphenylferrocenyl di-tert-butylphosphine (Q-phos), and the highly reactive dimeric Pd(I) complex {[P(t-Bu)3]PdBr}2. Zinc enolates, prepared from α-bromo esters and amides, react with aryl bromides to form α-aryl esters, e.g., I (R1 = OCMe3, R2 = H), and amides, e.g., I (R1 = NEt2, R2 = Me), in high yields, and with remarkable functional group tolerance. The second procedure; silyl ketenes II (R3 = t-Bu, R4 = H; R3 = R4 = Me) and silyl ketimine acetals react with aryl bromides in the presence of substoichiometric amounts of zinc fluoride, Pd(dba)2, and P(t-Bu)3 to give α-aryl esters and amides. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Formula: C12H15NO4
The Article related to zinc enolate aryl bromide arylation, aryl ester preparation, amide aryl preparation, palladium arylation catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Formula: C12H15NO4
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