On August 12, 2022, Liu, Jieqing; Li, Jie; Zhang, Peixi; Xia, Yuanxi; Ma, Junjie; Zhang, Ling; Wang, Qiaolai; Zhang, Ziqing published a patent.Related Products of 882518-89-0 The title of the patent was Preparation of icaritin PROTACs as antitumor agents. And the patent contained the following:
The invention relates to preparation of icaritin PROTACs as antitumor agents. In particular, icaritin protacs I [wherein E3 ligand is at least one in lenalidomide or VHL type ligand (V0), linker is at least one of aliphatic chain or PEG chain, described aliphatic chain is -(CH2)n1CO-NH(CH2)n2-, where n1 represents a natural number from 1 to 6, and n2 represents a natural number 4 or 5; described PEG chain is -(CH2CH2O)n1-CH2CO-NH(CH-R1)-, -(CH2CH2O)n1-CH2CO-NH(CH2)n2-, where n1 represents the natural number 2 or 3, R1 is a C5-alkyl group, and n2 represents the natural number 4 or 5] were prepared The present invention also relates to a process for the preparation of the above-mentioned icarisin PROTACs and the use thereof based on the antitumor activity of the target GRIA3. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Related Products of 882518-89-0
The Article related to icaritin protac preparation antitumor agent, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Related Products of 882518-89-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics