On March 31, 2020, Saunders, Leslie J.; Hoffman, Alex D.; Nichols, John W.; Gobas, Frank A. P. C. published an article.Application of 6197-30-4 The title of the article was Dietary Bioaccumulation and Biotransformation of Hydrophobic Organic Sunscreen Agents in Rainbow Trout. And the article contained the following:
The present study investigated the dietary bioaccumulation and biotransformation of hydrophobic organic sunscreen agents, 2-ethylhexyl-4-methoxycinnamate (EHMC) and octocrylene (OCT), in rainbow trout using a modified Organization for Economic Co-operation and Development 305 dietary bioaccumulation test that incorporated nonbiotransformed reference chems. Trout were exposed to 3 dietary concentrations of each chem. to investigate the relationship between dietary exposure concentration and observed accumulation and depuration. Both EHMC and OCT were significantly biotransformed, resulting in mean in vivo whole-body biotransformation rate constants (kMET) of 0.54 ± 0.06 and 0.09 ± 0.01 d-1, resp. The kMET values generated for both chems. did not differ between dietary exposure concentrations, indicating that chem. concentrations in the fish were not high enough to saturate biotransformation enzymes. Both somatic and luminal biotransformation substantially reduce EHMC and OCT bioaccumulation potential in trout. Biomagnification factors (BMFs) and bioconcentration factors (BCFs) of EHMC averaged 0.0035 kg lipid kg lipid-1 and 396 L kg-1, resp., whereas those of OCT averaged 0.0084 kg lipid kg lipid-1 and 1267 L kg-1. These values are 1 to 2 orders of magnitude lower than the BMFs and BCFs generated for reference chems. of similar log KOW. In addition, for both chems., derived BMFs and BCFs fell below established bioaccumulation criteria (1.0 kg lipid kg lipid-1 and 2000 L kg-1, resp.), suggesting that EHMC ad OCT are unlikely to bioaccumulate to a high degree in aquatic biota. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Application of 6197-30-4
The Article related to dietary bioaccumulation biotransformation hydrophobic organic sunscreen rainbow trout, bioaccumulation, biomagnification, biotransformation, sunscreens, toxicokinetics, ultraviolet filters and other aspects.Application of 6197-30-4
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