On September 6, 2022, Kumar Singh, Adesh; Venkatesh, Rapelly; Kumar Kanaujiya, Vimlesh; Tiwari, Varsha; Kandasamy, Jeyakumar published an article.Electric Literature of 2873-29-2 The title of the article was Palladium-Catalyzed Reaction of Aryl Iodides and Glycal Enones: Application in the Preparation of Dapagliflozin Analogues. And the article contained the following:
An efficient approach for the preparation of C-1 aryl enones from aryl iodides and glycal enones by palladium-catalyzed cross-coupling reactions under ligand-free conditions was developed. A wide range of aryl iodides bearing electron-donating and withdrawing groups underwent oxidative C-1 arylation with galactal, glucal and rhamnal enones in the presence of Pd(OAc)2 and AgNO3 under mild conditions. The protecting groups, including benzyl, acetyl, pivaloyl, and benzoyl groups, were found to be compatible under standard reaction conditions. The developed methodol. was applied for the preparation of dapagliflozin analogs (SGLT-2 inhibitors, no biol. data). Regioselective nitration of C-1 aryl enones provides C-2 nitro aryl enones in good yields. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Electric Literature of 2873-29-2
The Article related to oxidative arylation protecting group sglt2 dapagliflozin, glycoside dapagliflozin analog preparation nitration regioselective cross coupling, palladium catalyzed aryl iodide glycal enone dapagliflozin analog preparation and other aspects.Electric Literature of 2873-29-2
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