On April 10, 2003, Dhar, T. G. Murali; Potin, Dominique; Maillet, Magaili Jeannine Blandine; Launay, Michele; Nicolai, Eric Antoine; Iwanowicz, Edwin J. published a patent.Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Preparation of spiro-hydantoin compounds useful as anti-inflammatory agents. And the patent contained the following:
Title compounds I [L and K independently = O or S; X = N or CR3; Ar = aryl or heteroaryl; G is attached via T or M with provision when attached to C, G = bond, O, N, S, (un)substituted alkylene, bivalent alkoxy, etc., when G is attached to N, G = bond, (un)substituted alkylene, bivalent acyl or alkoxycarbonyl, and a bivalent alkoxy, alkylthio, aminoalkyl, sulfonyl, or sulfonamidyl wherein each of said G groups have at least one carbon atom attached to ring A; T = T1 when G-Ar is attached to T, and T2 when G-Ar is attached to M; M = M1 when G-Ar is attached to M, and M2 when G-Ar is attached to T; T1 and M1 = N, CR5; T2 and M2 = O, S, -N=, SO2, etc.; R1, R2, and R3 independently = H, halo, (un)substituted-alkyl, -alkenyl, NO2, etc.; R4 = H, (un)substituted alkyl, OH, NH2, alkoxy, etc.; R5 = H, (un)substituted alkyl, halo, CN, OH, etc.; J = O, S, -N=, SO2, substituted N, etc.; ], and pharmaceutically-acceptable salts, hydrates,enantiomers, and diastereomers, and prodrugs thereof, (I) are prepared and disclosed as inhibitors of LFA-1/ICAM and as anti-inflammatory agents. Thus, II was prepared by base catalyzed cyclization of 1-bromo-4-(1,4-dibromobutyl)benzene (preparation given) with 3-(3,5-dichlorophenyl)-1-methylimidazolidine-2,4-dione. Assays indicated I have a measurable level of activity as inhibitors of LFA-1 and/or ICAM (no data). The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
The Article related to hydantoin spiro preparation antiinflammatory nsaid lfa1 icam, spiro pyrrole imidazolinedione preparation, lymphocyte function associated antigen inhibitor spirohydantoin, intercellular adhesion mol inhibitor spirohydantoin and other aspects.Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics