On April 11, 2002, Kaila, Neelu; Chen, Lihren; Thomas, Bert E. IV; Tsao, Desiree; Tam, Steve; Bedard, Patricia W.; Camphausen, Raymond T.; Alvarez, Juan C.; Ullas, Giliyar published an article.Safety of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the article was β-C-Mannosides as Selectin Inhibitors. And the article contained the following:
Potential E- and P-selectin inhibitors were synthesized to explore a hydrophobic area on the E-selectin surface and the PSGL-1 protein binding site on the P-selectin surface that was recently defined by crystallog. Three series of mannose-based compounds (libraries A, B, and C) were synthesized using solution phase parallel synthesis. Biol. evaluation of these compounds was done using two ELISA-based assays and transferred NOE (trNOE) experiments Some of the compounds showed better activity than sLex in the P-selectin assay. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Safety of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
The Article related to combinatorial library mannoside preparation selectin inhibitor glycoprotein, structure activity mannoside preparation selectin inhibitor glycoprotein, aminodeoxy glycoside mannoside preparation selectin inhibitor glycoprotein psgl and other aspects.Safety of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics