Bao, Deng-Hui; Wu, Hui-Ling; Liu, Chao-Lun; Xie, Jian-Hua; Zhou, Qi-Lin published an article in 2015, the title of the article was Development of Chiral Spiro P-N-S Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of β-Alkyl-β-Ketoesters.Electric Literature of 3976-69-0 And the article contains the following content:
The chiral tridentate spiro P-N-S ligands, e.g., I, (SpiroSAP) were developed, and their iridium complexes were prepared Introduction of a 1,3-dithiane moiety into the ligand resulted in a highly efficient chiral iridium catalyst for asym. hydrogenation of β-alkyl-β-ketoesters, producing chiral β-alkyl-β-hydroxyesters, e.g., II, with excellent enantioselectivities (95-99.9 % ee) and turnover numbers of up to 355000. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Electric Literature of 3976-69-0
The Article related to tridentate spiro ligand preparation iridium complexation, enantioselective alkyl hydroxyester preparation, alkyl ketoester asym hydrogenation iridium catalyst, asymmetric catalysis, hydrogenation, iridium, ketoesters, spiro ligands and other aspects.Electric Literature of 3976-69-0
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