On February 1, 2022, Nielsen, Michael Martin; Holmstroem, Thomas; Pedersen, Christian Marcus published an article.Recommanded Product: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate The title of the article was Stereoselective O-Glycosylations by Pyrylium Salt Organocatalysis. And the article contained the following:
Despite many years of invention, the field of carbohydrate chem. remains rather inaccessible to non-specialists, which limits the scientific impact and reach of the discoveries made in the field. Aiming to increase the availability of stereoselective glycosylation chem. for non-specialists, we have discovered that several com. available pyrylium salts catalyze stereoselective O-glycosylation of a wide range of phenols and alkyl alcs. This catalytic reaction utilizes trichloroacetimidates, an easily accessible and synthetically proven electrophile, takes place under air and only initiates when all three reagents are mixed, which should provide better reproducibility by non-specialists. The reaction exhibits varying degrees of stereospecificity, resulting in β-selective glycosylation from α-trichloroacetimidates, while an α-selective glycosylation proceeds from β-trichloroacetimidates. A mechanistic study revealed that the reaction likely proceeds via an SN2-like substitution on the protonated electrophile. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Recommanded Product: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate
The Article related to amino acid disaccharide glycoside preparation glycosylation cytotoxicity, stereoselective glycosylation catalyze organocatalysis pyrylium salt glycoside preparation chloroacetimidate, catalysis, kinetics, pyrylium, stereospecific glycosylation mechanism and other aspects.Recommanded Product: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics