Loenarz, Christoph; Mecinovic, Jasmin; Chowdhury, Rasheduzzaman; McNeill, Luke A.; Flashman, Emily; Schofield, Christopher J. published the artcile< Evidence for a stereoelectronic effect in human oxygen sensing>, Synthetic Route of 112-63-0, the main research area is stereoelectronic effect human oxygen sensing; proline conformation prolyl hydroxylase pVHL specificity.
How PHDs achieve specificity: trans-4-prolyl hydroxylation of the transcription factor HIF occurs with stereochem. retention. Substrate-analog studies show how the von Hippel Lindau tumor suppressor protein (pVHL) and the oxygen-sensing hydroxylases (PHDs) achieve specificity for hydroxyprolyl/prolyl residues for the C4-exo/endo prolyl conformations, resp.
Angewandte Chemie, International Edition published new progress about Homo sapiens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics