A common heterocyclic compound, 541-16-2, name is Di-tert-Butyl malonate, molecular formula is C11H20O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 541-16-2.
To a suspension of benzyltriethylamrnonium chloride (21.0 g, 92.2 mmol) in a 50% aqueous NaOH solution (92.4 g in 185 mL H2O) was added 1,2-dibromobutane (30.0 g, 138.9 mmol) and di-tert-butylmalonate (20.0 g, 92.5 mmol). The reaction mixture was vigorously stirred 18 h at rt, a mixture of ice and water was then added. The crude product was extracted with CH2Cl2 (3¡Á) and sequentially washed with water (3¡Á), brine and the organic extracts combined. The organic layer was dried (MgSO4), filtered and concentrated in vacuo. The resulting residue was flash chromatographed (100 g SiO2, 3% Et2O in hexane) to afford the titled product (18.3 g, 67.8 mmol, 73% yield) which was used directly in the next reaction.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Di-tert-Butyl malonate, its application will become more common.
Reference:
Patent; Tu, Yong; Scola, Paul Michael; Good, Andrew Charles; Campbell, Jeffrey Allen; US2005/143316; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics