Wiesler, Stefan; Bau, Michael A.; Niepel, Thomas; Younas, Sara L.; Luu, Hieu-Trinh; Streuff, Jan published the artcile< Synthesis of α,ω-Bis-Enones by the Double Addition of Alkenyl Grignard Reagents to Diacid Weinreb Amides>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is enone preparation double addition alkenyl Grignard diacid Weinreb amide.
An efficient double addition of substituted alkenylmagnesium bromides to bis-Weinreb amides has been developed, giving α,ω-bis-enones that are building blocks for certain drugs and polymers. Furthermore, reliable protocols for the preparation of the required substituted alkenylmagnesium reagents from substituted non-activated alkenyl bromides are reported. The double addition is demonstrated on 25 examples, including enantiopure as well as conjugated and cross-conjugated bis-enones. The addition to a cyclohexane-1,2-dicarboxamide was found to lead to a selective mono addition, giving access to cyclohexyl γ-ketoamides that are core motifs of several pharmaceutical agents and promising drug candidates.
European Journal of Organic Chemistry published new progress about Addition reaction (double). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics