Palomba, Martina’s team published research in Tetrahedron in 2018-12-13 | 112-63-0

Tetrahedron published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Palomba, Martina; Sancineto, Luca; Marini, Francesca; Santi, Claudio; Bagnoli, Luana published the artcile< A domino approach to pyrazino-indoles and -pyrroles using vinyl selenones>, Category: esters-buliding-blocks, the main research area is indolecarboxamide pyrrolocarboxamide chemoselective regioselective Michael reaction cyclization vinyl selenone; pyrazinoindolone dihydro preparation; pyrrolopyrazinone dihydro preparation.

An efficient and flexible approach to biol. relevant 3,4-dihydropyrazino[1,2-a]indol-1(2H)ones I [R1 = H, F, Cl, MeO, R2 = H; R1 = R2 = MeO; R3 = n-Bu, Ph, PhCH2, (R)-PhCHMe, etc.; R4 = H, Me, n-Bu, n-hexyl] and 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)ones through a domino Michael/intramol. nucleophilic substitution pathway using potassium hydroxide in dichloromethane is disclosed. Variously substituted vinyl selenones R4CH:CHSeO2Ph and 1H-indole-2-carboxamides II or 1H-pyrrole-2-carboxamides were employed with success in chemo- and regioselective processes. The introduction of an amino acid portion on the amidic function is well tolerated without racemization.

Tetrahedron published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics