Guan, Ting; Guo, Jing-Yu; Zhang, Qing-Hong; Xu, Xin-Wen; Yu, Xiao-Yu; Zhang, Yu; Zhao, Kai published the artcile< Photoredox-catalyzed regio- & stereoselective C(sp2)-H cyanoalkylation of enamides with cycloketone oximes via selective C-C bond cleavage/radical addition cascade>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cyanoalkyl enamide preparation regioselective diastereoselective green chem; enamide cycloketone oxime Heck type cyanoalkylation photoredox catalyst.
A photoredox-catalyzed regio- and stereoselective Heck-type cyanoalkylation of synthetically prominent enamides R1C(=CH2)N(R2)(R3) (R1 = Ph, thiophen-3-yl, 2H-1,3-benzodioxol-5-yl, etc.; R2 = Ac, Bn; R3 = Bn, Me, cyclohexylmethyl, etc.) with cycloketone oximes I (Y = CH, N; R4 = H, n-C6H13, cyclohexylmethyl, Bn, etc.; R5 = H, Ph, CN, Boc, etc.; n = 1, 2) via selective β-C-C bond scission/selective radical addition cascade is developed, enabling the incorporation of synthetically versatile and pharmaceutically appealing distal cyanoalkyl moieties into enamide scaffolds R1C(N(R2)(R3))=CHCH(R4)Y(R5)(CH2)nCN under mild conditions. The synthetic importance of this methodol. was highlighted by the broad substrate scopes, satisfying functional group compatibilities, excellent regio- and stereoselectivities as well as the versatile and diverse synthetic applications of β-cyanoalkylated enamides.
Green Chemistry published new progress about Aliphatic nitriles Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics