Mullah, Nasreen N.; Sopchik, Alan E.; Bentrude, Wesley G. published the artcile< Effect on chair-chair equilibrium of 3-substituted-1,3,2-oxazaphosphorinanes of replacement of Me2N substituent on phosphorus by isoPr2N>, Application of C19H34O2, the main research area is substituent effect conformation dioxaphosphorinane; NMR substituent effect conformation dioxaphosphorinane.
The chair-chair conformational equilibrium (A (I) ⇌ B (II)) (R = Ph, Me, isoPr; R1 = H, Me) of 1,3,2-dioxaphosphorinanes featuring three-coordinated P substituted with an isoPr2N group (1-6) were studied by 1H NMR spectroscopy. Compared to the analogous series with an Me2N group on P, 1-6 populate the chair conformation B with R2N equatorial to a greater extent. This is interpreted to mean that conformer A is more destabilized by a greater steric size of isoPr2N than is conformer B. Thus, the repulsive interactions between equatorial Me2N and the substituent on N3, believed to be responsible for depopulation of B that result in an unexpectedly high population of A with Me2N on P, is overcome by destabilization of A by the axial isoPr2N. The apparent size effect of substituents on N3 in destabilization of B follows the order Ph > isoPr > Me, as observed earlier for the series with Me2N group on P.
Heteroatom Chemistry published new progress about Conformation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics