Wu, Qing-Juan; Lv, Wen-Liang; Li, Juan-Mei; Zhang, Ting-Ting; Zhou, Wen-Hui; Zhang, Qiang; Wang, Jiu-Chong; Wang, Qing-Nan; Yao, Zi-Ang; Qiang, Rui; Chen, Si-Tong; Zhao, Xin; Liu, Shuang; Cao, Zheng-Min; Xu, Lei; Li, Gao-Hui; Chen, Jing; Wang, Li published the artcile< YinQiSanHuang Jiedu decoction for the treatment of hepatitis B-related compensated liver cirrhosis: study protocol for a multi-center randomized controlled trial>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is YinQiSanHuang Jiedu decoction hepatitis B liver cirrhosis treatment.
Hepatitis B-related compensated liver cirrhosis is related to a higher risk of hepatocellular carcinoma, and antiviral therapy is the preferred method. As the pathol. mechanisms of liver fibrosis are complex, drugs developed for a single target are difficult to be effective in clin. practice, so there are no chem. drugs or biol. drugs with clear efficacy available for clin. application at present. Traditional Chinese medicine is a kind of medical science that has been gradually formed during thousands of years and continuously enriched by the people of all ethnic groups in China. Traditional Chinese medicine shows curative effects in the treatment of liver diseases, especially in the field of liver fibrosis prevention and treatment. This study aims to test the integrative medicine (Chinese medicine plus antiviral therapy) effective on lowing hepatocellular carcinoma risk among patients with hepatitis-related compensated liver cirrhosis. This is a multi-center randomized controlled trial, and a total of 5 hospitals and 802 patients will be involved in. All the subjects are randomly allocated to the YinQiSanHuang Jiedu decoction (YQSHD) group (n = 401) or the placebo group (n = 401). The YQSHD group receives YQSHD granule with entecavir (ETV), and the placebo group receives YQSHD placebo with ETV. The treatment period will last for 52 wk, and the follow-up period for 52 ± 2 wk. The primary outcome measure is the annual incidence of HCC. Outcomes will be assessed at baseline and after treatment. The objective of this trial is ′′the integrative of YQSHD with ETV reduce the annual incidence of HCC to 1%′′. The protocol has been approved by the Medical Ethics Committee of Guang′anmen Hospital, China (Number2019-006-KY), and the other centers in the trial will not begin recruiting until the local ethical approval has been obtained. Trial final results will be disseminated via publication.
Trials published new progress about Amino acids Role: NPO (Natural Product Occurrence), PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), OCCU (Occurrence), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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