Adding a certain compound to certain chemical reactions, such as: 34846-90-7, name is Methyl 3-methoxyacrylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34846-90-7, Safety of Methyl 3-methoxyacrylate
6-Hydrazino-N,N-dimethyl-pyrimidin-4-amine (0.40 g, 2.61 mmol) and methyl-3-methoxyprop-2-enoate (606 mg, 5.22 mmol) in MeOH (4 ml_) was heated to 130¡ãC in the microwave for 1 h. Further methyl-3-methoxyprop-2-enoate (303 mg, 2.61 mmol) was added and reaction was heated at 130¡ãC for a further 1 h. The reaction mixture was evaporated and purified by column chromatography eluting with DCM/NH3 2 M in MeOH (100:0 to 95:5). The recovered starting hydrazine, the uncyclised intermediate and methyl -3-methoxyprop-2-enoate (1.0 ml_) in MeOH (5.0 ml_) were heated in a microwave at 130¡ãC for 2 h. The crude was evaporated to dryness and purified by column chromatography eluting with DCM/NH3 2 M in MeOH (100:0 to 97:3). The product from both columns was slurried in MeOH (2.0 ml_) and filtered to give after drying the title compound as a white solid (62 mg, 11percent). LCMS (QC Acidic method): Rt = 2.59 min; [MH]+ = 206.0; >99.5percent purity 1H NMR (400 MHz; DMSO-cfe, d): 12.8 (1H, bs), 8.4 (1H, d), 7.6 (1H, bs), 7.0 (1H, bs), 5.5 (1H, bs) and 3.1 (6H, s)
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; CADO BIOTECHNOLOGY IVS; CRUMPLER, Simon Ross; DALBY-BROWN, William; PALLIN, Thomas David; HANSEN, John Bondo; WINTHER, Anne-Marie Lund; (240 pag.)WO2019/141957; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics