Bebell, Lisa M.; Parks, Kalynn; Le, Mylinh H.; Ngonzi, Joseph; Adong, Julian; Boatin, Adeline A.; Bassett, Ingrid V.; Siedner, Mark J.; Gernand, Alison D.; Roberts, Drucilla J. published the artcile< Placental decidual arteriopathy and vascular endothelial growth factor A expression among women with or without human immunodeficiency virus>, Reference of 112-63-0, the main research area is placental decidual arteriopathy HIV infection VEGFA; Africa; Malperfusion; histology; immunohistochemistry; intra-uterine growth restriction; pathology; pregnancy; pregnant; resource-limited; small for gestational age.
Women with human immunodeficiency virus (HIV) (WHIV) are at higher risk of adverse birth outcomes. Proposed mechanisms for the increased risk include placental arteriopathy (vasculopathy) and maternal vascular malperfusion (MVM) due to antiretroviral therapy and medical comorbid conditions. However, these features and their underlying pathophysiol. mechanisms have not been well characterized in WHIV. We performed gross and histol. examination and immunohistochem. staining for vascular endothelial growth factor A (VEGF-A), a key angiogenic factor, on placentas from women with ≥1 MVM risk factors including: weight below the fifth percentile, histol. infarct or distal villous hypoplasia, nevirapine-based antiretroviral therapy, hypertension, and preeclampsia/eclampsia during pregnancy. We compared pathol. characteristics by maternal HIV serostatus. Twenty-seven of 41 (placentas 66%) assessed for VEGF-A were from WHIV. Mean maternal age was 27 years. Among WHIV, median CD4 T-cell count was 440/μL, and the HIV viral load was undetectable in 74%. Of VEGF-A-stained placentas, both decidua and villous endothelium tissue layers were present in 36 (88%). VEGF-A was detected in 31 of 36 (86%) with decidua present, and 39 of 40 (98%) with villous endothelium present. There were no differences in VEGF-A presence in any tissue type by maternal HIV serostatus (P = .28 to >.99). MVM was more common in placentas selected for VEGF-A staining (51 vs 8%; P < .001). VEGF-A immunostaining was highly prevalent, and staining patterns did not differ by maternal HIV serostatus among those with MVM risk factors, indicating that the role of VEGF-A in placental vasculopathy may not differ by maternal HIV serostatus. Journal of Infectious Diseases published new progress about Anti-HIV agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics