Feenstra, R. W.; Stokkingreef, E. H. M.; Nivard, R. J. F.; Ottenheijm, H. C. J. published the artcile< An efficient synthesis of N-hydroxy α-amino acid derivatives of high optical purity>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is hydroxy amino acid; substitution hydroxy ester triflate benzylhydroxylamine.
(S)-HOCHRCO2R1 (R = Me, R1 = Et; R = CH2Ph, CH2CHMe2, CH2CO2Me, R1 = Me) were treated with (CF3SO2)2O (Tf2O) to give (S)-TfOCHRCO2R1, which were treated in situ with PhCH2ONH2 to give 78-89% (R)-PhCH2ONHCHRCO2R1 via a SN2 reaction. (S)-PhCH2ONHCHPhCO2Me was prepared similarly from (R)-HOCHPhCO2Me. The optical purity of the products ranged from 76 to 100%.
Tetrahedron Letters published new progress about Nucleophilic substitution reaction. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics