Martin-Saiz, Lucia; Guerrero-Mauvecin, Juan; Martin-Sanchez, Diego; Fresnedo, Olatz; Gomez, Manuel J.; Carrasco, Susana; Cannata-Ortiz, Pablo; Ortiz, Alberto; Fernandez, Jose A.; Sanz, Ana B. published the artcile< Ferrostatin-1 modulates dysregulated kidney lipids in acute kidney injury>, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is acute kidney injury ferrostatin1 lipidome lipid metabolism; Ferrostatin-1; acute kidney injury; ferroptosis; lipidomics; lyso-sulfatide; nephrotoxicity; phosphatidylethanolamine; phosphatidylinositol.
Ferroptosis, a form of regulated necrosis characterized by peroxidation of lipids such as arachidonic acid-containing phosphatidylethanolamine (PE), contributes to the pathogenesis of acute kidney injury (AKI). We have characterized the kidney lipidome in an exptl. nephrotoxic AKI induced in mice using folic acid and assessed the impact of the ferroptosis inhibitor Ferrostatin-1. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) was used to assess kidney lipidomics and it discriminated between glomeruli, medulla, and cortex in control kidneys, AKI kidneys, and AKI + Ferrostatin-1 kidneys. Out of 139 lipid species from 16 classes identified, 29 (20.5) showed significant differences between control and AKI at 48 h. Total PE and lyso-sulfatide species decreased, while phosphatidylinositol (PI) species increased in AKI. Dysregulated mRNA levels for Pemt, Pgs1, Cdipt, and Tamm41, relevant to lipid metabolism, were in line with the lipid changes observed Ferrostatin-1 prevented AKI and some AKI-associated changes in lipid levels, such as the decrease in PE and lyso-sulfatide species, without changing the gene expression of lipid metabolism enzymes. In conclusion, changes in the kidney lipid composition during nephrotoxic AKI are associated with differential gene expression of lipid metabolism enzymes and are partially prevented by Ferrostatin-1. 2022 The Pathol. Society of Great Britain and Ireland.
Journal of Pathology published new progress about Acute kidney injury. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate.
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