Application of 207346-42-7,Some common heterocyclic compound, 207346-42-7, name is Methyl 2-amino-4,5-difluorobenzoate, molecular formula is C8H7F2NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Into a 500mL round bottom flask equipped with a magnetic stir bar was placed methyl 2-amino-6-methoxybenzoate (25 g, 149.6 mmol), ethanol (200 mL), cyanamide (9.43 g, 224 mmol), and concentrated HCl (6 mL). The mixture was allowed to stir at reflux for 6 hours. At one hour intervals, concentrated HCl (0.5 mL) was added. The reaction mixture was allowed to cool to room temperature and the solid, 7i, was isolated via filtration and washed with ethanol. 1H NMR (400 MHz, DMSO-d6) delta ppm 3.88 (s, 3 H), 6.96 (dd, J=8.2, 3.1 Hz, 2 H), 7.69 (t, J=8.3 Hz, 1 H), 8.28 (br. s., 2 H), 12.67 (br. s., 1 H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-amino-4,5-difluorobenzoate, its application will become more common.
Reference:
Article; Pieters, Serge; McGowan, David; Herschke, Florence; Pauwels, Frederik; Stoops, Bart; Last, Stefaan; Embrechts, Werner; Scholliers, Annick; Mostmans, Wendy; Van Dijck, Kris; Van Schoubroeck, Bertrand; Thone, Tine; De Pooter, Dorien; Fanning, Gregory; Rosauro, Mari Luz; Khamlichi, Mourad Daoubi; Houpis, Ioannis; Arnoult, Eric; Jonckers, Tim H.M.; Raboisson, Pierre; Bioorganic and Medicinal Chemistry Letters; vol. 28; 4; (2018); p. 711 – 719;,
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