Ni, Haiwei; Ruan, Guojing; Sun, Cheng; Yang, Xuan; Miao, Zhenyan; Li, Jifei; Chen, Ying; Qin, Hai; Liu, Yichen; Zheng, Lufeng; Xing, Yingying; Xi, Tao; Li, Xiaoman published the artcile< Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis>, Application In Synthesis of 347174-05-4, the main research area is tanshinone IIA gastric cancer cell stemness ferroptosis; SLC7A11; Tanshinone IIA; ferroptosis; gastric cancer; stemness.
Tanshinone IIA is the active constituent extracted from Salvia Miltiorrhza. Numerous studies have shown that Tanshinone IIA could inhibit tumor proliferation and metastasis, including gastric cancer. However, the effect of Tanshinone IIA on gastric cancer cell stemness stays unclear. Here, we found that Tanshinone IIA could reduce gastric cancer cell stemness through detecting spheroid-forming, flow cytometry anal., and the expression of stemness markers (OCT3/4, ALDH1A1, and CD44). Mechanistically, Tanshinone IIA increased the level of lipid peroxides and decreased glutathione level in gastric cancer cells, both of which are the markers of ferroptosis. Similarly, ferroptosis inducers (erastin, sulfasalazine, and sorafenib) reduced gastric cancer cell stemness. Addnl., the inhibitory effects of Tanshinone IIA on GC cell stemness were reversed by ferroptosis inhibitor (Fer-1) or overexpression of SLC7A11, which is a critical ferroptosis inhibitor. Therefore, we revealed that Tanshinone IIA inhibited the stemness of gastric cancer cells partly through inducing ferroptosis.
Environmental Toxicology published new progress about CD44 antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Application In Synthesis of 347174-05-4.
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Ester – an overview | ScienceDirect Topics