Hong, Suk Bong; Raushel, Frank M. published the artcile< Inhibitors directed towards the binuclear metal center of phosphotriesterase>, COA of Formula: C19H34O2, the main research area is phosphotriesterase cadmium zinc phosphonate phosphoramidate.
The potential roles in binding and catalysis for the binuclear metal center found within bacterial phosphotriesterase were evaluated by characterization of the inhibitory properties of 26 substrate and product mimetics. Phosphonates bearing monofluoro, difluoro, or hydroxyl substituents at the methylene position were noncompetitive inhibitors with Ki values ranging from 0.6-9 mM vs. the substrate paraoxon. Phosphoramidates did not inhibit the enzyme. Di-Et phosphate and di-Et dithiophosphate inhibited the Cd-substituted enzyme with Ki values of 10 and 130 μM, resp. The most effective inhibitor for either the Cd or Zn substituted enzyme was found di-Et thiomethyl-phosphonate. The competitive inhibition constants for this compound were 60 nM and 2.8 μM for the Cd- and Zn-substituted enzyme, resp. The tight binding is attributed to chelation of both metal ions simultaneously.
Journal of Enzyme Inhibition published new progress about Metalloenzymes Role: BAC (Biological Activity or Effector, Except Adverse), BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics