Kitagawa, Haruaki; Kitagawa, Ranna; Tsuboi, Ririko; Hirose, Nanako; Thongthai, Pasiree; Sakai, Hirohiko; Ueda, Mayuka; Ono, Shunka; Sasaki, Jun-Ichi; Ooya, Tooru; Imazato, Satoshi published the artcile< Development of endodontic sealers containing antimicrobial-loaded polymer particles with long-term antibacterial effects>, Safety of 2-Ethyl-2-((methacryloyloxy)methyl)propane-1,3-diyl bis(2-methylacrylate), the main research area is antimicrobial polymer particle endodontic sealer antibacterial effect; Antibacterial; Antimicrobial; Cetylpyridinium chloride; Drug delivery; Endodontic filling; Infection control; PolyHEMA/TMPT particle; Resin; Sealer; Sustained release.
The objective of this study is to prepare new dental resins with a long-lasting antimicrobial activity. Specifically, this study evaluates an approach for controlling infection in root canals using sealers containing polyhydroxyethyl methacrylate trimethylolpropane trimethacrylate (polyHEMA/TMPT) particles loaded with cetylpyridinium chloride (CPC). In addition, the phys. properties of sealers containing CPC-loaded polyHEMA/TMPT particles (CLP) are determined PolyHEMA/TMPT particles with 10 (10%-CLP) and 25 weight% CPC (25%-CLP) with different particle sizes were fabricated and incorporated in HEMA-based sealers. CPC-release profiles were evaluated over 14 days of immersion in water, followed by 14 days of storage and 14 days of water immersion. The antibacterial activity of these sealers against Enterococcus faecalis in dentinal tubules was assessed using a root-canal-infection model. Their sealing abilities were evaluated by fluid filtration and phys. properties were tested according to the ISO 6876 standard The long-term antibacterial activity of the cured sealer containing 25%-CLP (∼21 μm particle diameter) was re-assessed after 1 yr of storage. After 28 days of immersion, 25%-CLP exhibited a higher and sustained CPC release unlike 10%-CLP. Residual bacteria in root dentinal tubules were eradicated by obturation with 25%-CLP-containing sealers. The incorporation of 25%-CLP (∼21 μm) had no adverse effects on the sealing ability and phys. properties of the sealer and resulted in long-term antibacterial activity. The incorporation of CPC-loaded particles in HEMA resins yielded endodontic sealers with long-term bactericidal activity against E. faecalis in root canals. These sealers can potentially be used to prevent recurrent apical periodontitis.
Dental Materials published new progress about Antibacterial agents. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Safety of 2-Ethyl-2-((methacryloyloxy)methyl)propane-1,3-diyl bis(2-methylacrylate).
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics