Du, Wei; Gu, Qiangshuai; Li, Zhongliang; Yang, Dan published the artcile< Palladium(II)-Catalyzed Intramolecular Tandem Aminoalkylation via Divergent C(sp3)-H Functionalization>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is palladium catalyst intramol oxidative tandem aminoalkylation divergent functionalization; fused indoline preparation green chem.
We have developed a Pd(II)-catalyzed oxidative tandem aminoalkylation via divergent C(sp3)-H functionalization, affording three- and five-membered-ring fused indolines, e.g. I and II, in good yields under two optimized conditions, resp. The mechanism studies have indicated that the benzylic C-H cleavage involved in the former transformation is the rate-determining step, while the cleavage of amide α-C-H in the latter is not. This is the first example of a Pd-catalyzed tandem reaction involving C(sp3)-H activation without the employment of prefunctionalized reagents (e.g., halogenated and boron reagents) and directing groups, representing a green and economic protocol for the construction of N-containing heterocycles.
Journal of the American Chemical Society published new progress about Aminoalkylation (oxidative). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.
Referemce:
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