Application of 99548-54-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 99548-54-6 name is Methyl 3-bromo-2-methylbenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of compound 32-1 (7 g, 40 mmol), methyl 3-bromo-2-methylbenzoate (11 g, 48 mmol), K3P04 (25 g, 120 mmol), Pd2(dba)3 (915 mg, 1 mmol), X-phos (952 mg, 2 mmol) in 100 mL of dried toluene was heated under a N2 atmosphere at 100C for 18 h. Then water (200 mL) wasadded,and the mixture was extracted with ethyl acetate (3 x 100 mL). The combined organic layers were washed with brine (100 mL), dried over anhydrous Na2SO4 and concentrated to give the crude product. The crude product was purified by flash column chromatography on silica gel eluted with petroleum ether:ethyl acetate (3:1) to give 32-2. MS (ESI) m / e (M+H): 323.1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-bromo-2-methylbenzoate, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; HAGMANN, William K.; NARGUND, Ravi P.; BLIZZARD, Timothy A.; JOSIEN, Hubert; BIJU, Purakkattle; PLUMMER, Christopher W.; DANG, Qun; LI, Bing; LIN, Linus S.; CUI, Mingxiang; HU, Bin; HAO, Jinlai; CHEN, Zhengxia; WO2014/19186; (2014); A1;,
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