Davison, Holly R.; Solano, Danielle M.; Phuan, Puay-Wah; Verkman, A. S.; Kurth, Mark J. published the artcile< Fluorinated ΔF508-CFTR correctors and potentiators for PET imaging>, Synthetic Route of 112-63-0, the main research area is fluorinated F508 CFTR corrector potentiator PET imaging.
19F-modified bithiazole correctors and phenylglycine potentiators of the ΔF508-CFTR chloride channel were synthesized and their function assayed in cells expressing human ΔF508-CFTR and a halide-sensitive fluorescent protein. Fluorine was incorporated into each scaffold using prosthetic groups for future biodistribution imaging studies using positron emission tomog. (PET). The ΔF508-CFTR corrector and potentiator potencies of the fluorinated analogs were comparable to or better than those of the original compounds
Bioorganic & Medicinal Chemistry Letters published new progress about Amidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics