Electric Literature of 13195-64-7,Some common heterocyclic compound, 13195-64-7, name is Diisopropyl malonate, molecular formula is C9H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 2-(2-nitrovinyl)-phenol or 2-(2-nitrovinyl)-naphthol 1, base, Cat., and 1.5 mL solvent were added to an oven-dried tube, successively. Then malonate ester or related compound 2 and oxidant were added. The reaction mixture was then stirred in air until the reaction was nearly completed, as determined by TLC. Once 1 consumed, the reaction mixture was cooled to ambient temperature. The resulting mixture was concentrated in vacuo and directly purified by column chromatography (petroleum ether/ethyl acetate = 7:1-5:1) on silica gel to give the desired products 3.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Diisopropyl malonate, its application will become more common.
Reference:
Article; Leng, Jiaying; Meng, Jiang; Luo, Xiaoyan; Deng, Wei-Ping; Tetrahedron; vol. 74; 49; (2018); p. 6993 – 6999;,
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